Bring a large pot of salted water to a boil. Add the pasta and cook according to package instructions until al dente. Reserve 1/2 cup of the pasta water, drain the pasta, and set it aside.

In a bowl, toss the chicken pieces with Cajun seasoning, smoked paprika, garlic powder, and onion powder.

Heat olive oil in a large skillet over medium-high heat. Add the seasoned chicken and cook for 5-7 minutes, until golden brown and cooked through. Remove the chicken from the skillet and set aside.

In the same skillet, melt the butter over medium heat. Add minced garlic and sauté for about 1 minute until fragrant. Stir in heavy cream, Parmesan cheese, chicken broth, additional Cajun seasoning, and red pepper flakes. Cook for 3-4 minutes, stirring constantly, until the sauce thickens slightly.

Add the cooked pasta and chicken back into the skillet, tossing to coat everything in the creamy sauce. If the sauce is too thick, add reserved pasta water one tablespoon at a time until you reach desired consistency.

Taste and adjust the seasoning with salt and black pepper as needed. Garnish with fresh parsley and extra Parmesan cheese if desired.

Serve immediately while hot, and consider pairing it with garlic bread or a fresh green salad for a complete meal.